Search on: PROTEIN AGGREGATION, PATHOLOGICAL 
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Descriptor English:   Protein Aggregation, Pathological 
Descriptor Spanish:   Agregación Patológica de Proteínas 
Descriptor Portuguese:   Agregação Patológica de Proteínas 
Tree Number:   C23.550.770
G02.111.668
Definition English:   A biochemical phenomenon in which misfolded proteins aggregate either intra- or extracellularly. Triggered by factors such as MUTATION, POST-TRANSLATIONAL MODIFICATIONS, and environmental stress, it is generally associated with ALZHEIMER DISEASE; PARKINSON DISEASE; HUNTINGTON DISEASE; and TYPE 2 DIABETES MELLITUS. 
See Related English:   Protein Aggregates
 
History Note English:   2015 
Allowable Qualifiers English:  
BL blood CF cerebrospinal fluid
CI chemically induced CL classification
CO complications CN congenital
DI diagnosis DH diet therapy
DT drug therapy EC economics
EM embryology EN enzymology
EP epidemiology EH ethnology
ET etiology GE genetics
HI history IM immunology
ME metabolism MI microbiology
MO mortality NU nursing
PS parasitology PA pathology
PP physiopathology PC prevention & control
PX psychology RA radiography
RI radionuclide imaging RT radiotherapy
RH rehabilitation SU surgery
TH therapy US ultrasonography
UR urine VE veterinary
VI virology  
Record Number:   55596 
Unique Identifier:   D066263 

Occurrence in VHL: 		 

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